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Business

Why the new Novavax Covid vaccine will not win over unvaccinated Americans




Unvaccinated Americans will soon be able to choose a new type of shot to protect themselves against the ever-evolving Covid-19 virus: the Novavax vaccine.

The descendant of the Covid shot has raised hopes of wider acceptance among vaccine skeptics. It uses traditional protein-based technology, unlike its mRNA counterparts. But experts say it still can’t convince a large number of unwilling holdouts to roll up their sleeves and get vaccinated.

“I do not think a shot like Novavax with worn-out technology will suddenly convince unvaccinated people to say, ̵[ads1]6;Now I want a vaccine, now I think a vaccine will keep me away from the hospital and the intensive care unit,'” Dr. Paul Offit, director of the Vaccine Education Center at the Children’s Hospital of Philadelphia and a member of an independent advisory group to the U.S. Food and Drug Administration, tells CNBC Make It.

On Wednesday, the FDA approved the Novavax syringe for adults 18 years and older. Once approved by the Centers for Disease Control and Prevention, it will only be available as a two-dose primary series, instead of a booster – meaning that only unvaccinated Americans will be able to receive it.

According to CDC data from the beginning of June, approximately 27 million American adults have still not received a single Covid shot, which is a significant obstacle to US attempts to finally force Covid into a manageable, endemic phase. The United States is already struggling with yet another increase in Covid cases – this time, driven by highly transmissible omicron sub-variants such as BA.5 – and unless the country’s vaccination rate improves, a more serious variant of concern may soon emerge.

Here’s how Novavax’s Covid vaccine can help, and why many unvaccinated people can still pass it on.

The new vaccine’s appeal to people who are afraid of mRNA technology

The Novavax shot is the fourth Covid shot to achieve FDA approval in the United States and the first to use protein technology – a decades-old method of virus control used in several routine vaccinations, such as against hepatitis B and shingles.

It is very effective, according to clinical data: Two doses were 90% effective in preventing Covid disease when tested in a study involving around 30,000 adults aged 18 years and older, according to the FDA. In particular, the research was conducted from December 2020 to September 2021, a few months before the emergence of Covid’s omicron variant.

Novavax’s shots work differently than their mRNA counterparts, but achieve the same result: Teach your body how to fight Covid. It injects copies of the spike protein – a molecule found on the coronavirus – and an ingredient called adjuvant into the body’s cells, which induces an immune response against the virus.

“Novavax uses essentially the same approach as mRNA vaccines, but they make the protein in a factory. So they give you the protein itself, instead of instructing your cells to make a protein,” says Dr. Robert Schooley, an infectious person. . disease specialist at UC San Diego Health.

Guy Palmer, professor of pathology and infectious diseases at Washington State University, says the Novavax vaccine could potentially appeal to Americans who mistakenly believe that mRNA vaccines are unsafe, due to the technology’s perceived innovation and a misconception that they can alter human DNA.

“There’s a small open door there for a non-mRNA vaccine like Novavax,” says Palmer.

Vaccine denial is a cultural problem

Unvaccinated Americans may perceive protein-based shots as safer than mRNA: In a Morning Consult survey last week, approximately 28% of unvaccinated individuals surveyed said they viewed protein-based shots as safe, while only 17% said the same about mRNA vaccines. .

But 77% still said they would not get a protein-based Covid syringe if it was authorized in the United States

Offit points to a major problem at hand: Vaccine denial has become a cultural problem, regardless of the technology behind the shootings. He says that many unvaccinated Americans, especially those who are politically right-wing, are now driven by fixed ideas such as distrust of the government.

In a poll by the Kaiser Family Foundation published in May, only 14% of Republicans surveyed said they had “a good deal or a good deal of trust” in President Joe Biden to provide reliable information on Covid vaccines. The poll also shows that Republicans are among those with the lowest vaccination rates, with only 55%.

Even today’s most common anti-vaccination argument – that vaccines are meaningless because they can not always prevent breakthrough infections – can be a cover for that kind of wired idea. (No vaccine is ever 100% effective, and staying up to date on your Covid vaccines can significantly reduce the chances of serious illness, hospitalization, or death.)

“Some say they do not want an mRNA vaccine, so this protein vaccine may be an option. But others may say I simply do not like vaccines, period. Or I do not trust the FDA or the government,” Schooley says. “Giving rational explanations and alternatives like Novavax that addresses some concerns does not necessarily get you past the fact that it is just a reluctance to be vaccinated.”

The Novavax vaccine is still good news

The shot’s entry into the US market may still be good news, says Dr. Dean Blumberg, head of the Department of Pediatric Infectious Diseases at UC Davis Health.

Another source of vaccine supply is “always good to have” in case other companies have production difficulties, says Blumberg. It can ensure that an incident similar to the recent lack of infant formula will not happen with Covid vaccines, he adds.

Blumberg also emphasizes that any progress in getting holdouts vaccinated should be celebrated.

“I’m not sure how many of the remaining unvaccinated people in the United States will be interested in getting this Novavax vaccine – but it’s another tool in the toolbox,” he says. “Even if only a few people benefit from being vaccinated with it, it’s great.”

Offit says Novavax could have a bigger impact on the road: Its omicron-specific booster shots may be ready for federal approval this fall or winter, and preclinical data show they could potentially provide improved immunity to omicron and its variants.

“You have a certain section of the population who are obviously interested in getting as many doses as possible,” says Offit, adding that people may view a Novavax booster as “an advantage” over a shot that is. same as their previous doses.

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