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As Novo Nordisk begins PhII sickle cell trial, it gets late-stage blood disease drug in $1.1 billion Forma buy – Endpoints News




Lumakras, Amgen’s breakthrough KRAS drug, was approved based on data from an open-label, single-arm study that, among other things, suggests a median progression-free survival of 6.8 months for patients with KRASG12C-mutated non-small cell lung cancer.

Now Amgen says it has the first evidence that Lumakras beats chemotherapy — the current standard of care — on that metric.

Additional analyzes are still ongoing, and data will be reserved for future medical conferences, Amgen said, remaining tight-lipped. What that means is that the drug, formerly known as sotorasib, met the primary endpoint of PFS in the CodeBreaK 200 trial, where it went head-to-head with intravenous docetaxel. Among 345 patients, Lumakras showed “statistical significance and superiority”[ads1]; over the chemotherapy.

As Novo Nordisk begins PhII sickle cell trial, it gets late-stage blood disease drug in .1 billion Forma buy – Endpoints News

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